Description
Advantage of using Ketotifen
So what will ketotifen do regarding our research that no other compound will be? Well, when administered with a beta 2 adrenergic agent such as clenbuterol or albuterol, it will allow the compound to remain effective for a longer duration, at a lower effective dose. This eliminates the need to dangerously administer very high doses to research subjects who may come with higher risks and unwanted side effects. It also allows us to administer beta 2 agonist continuously without reducing the effectiveness. This will lead us to observe much faster results in our research than if we were required to stop administration or to adapt a protocol of 2 weeks on, 2 weeks off to our research subjects.
How does Ketotifen work?
Ketotifen has 2 primary effects. First of all, it is an antihistamine h1. There are 2 types of antihistamines, h1 and h2. A primary difference is h1 antihistamines cross the blood brain barrier in research subjects and are known to induce drowsiness as a result of this. Ketotifen, being an h1 antihistamine, is known to induce this effect. Second, it is a mast cell stabilizer. Mast cells are cells rich in histamine. They are activated by the calcium channel transfer; ketotifen blocks this calcium channel transfer. This is particularly remarkable that clenbuterol, via cAMP, activates this calcium channel transfer.
The synergy between clenbuterol and ketotifen in research subjects is complicated to say the least. In fact, in all reality, they exhibit antihistamine effects, but while displaying a synergy to make the other more effective. Just as ketotifen prevents down regulation of beta 2 receptors, clenbuterol prevents the same effect in histamine receptors! Fortunately for our purposes there is a definitive study which proves that the addition of ketotifen increases the effectiveness of Clenbuterol in research subjects. There is also a study that proves its effects on preventing the regulation of the d2 adrenergic receptor b2. Sometimes science makes it a little easier. Publications, peer-reviewed studies proving the effectiveness and synergy of XNUMX research compounds.
