Insulin in bodybuilding

Insulin also promotes the diffusion of glucose from cells via insulin receptors. Very high concentrations of insulin result in protein synthesis by the strongly stimulated muscle. It does this primarily by enhancing the initiation of the peptide chain.

These results make it more interesting for bodybuilders and athletes. This is because these factors combine to make proteins ingested more efficiently, by promoting the transport of amino acids in muscle cells.

We can clearly say that insulin is without a doubt the essential anabolic for muscle tissue. It also increases bone density. Another mechanism that increases the anabolic effect of insulin is that insulin increases your IGF levels (Insulin-like Growth Factor) in your body. No need to remind you that IGF-1 is a very anabolic hormone.

Another unexpected aspect of insulin is its ability to increase the levels of LH (Leutenizing Hormone) and FSH (Folliculo-Stimulating Hormone). So this means that insulin stimulates the secretion of gonadotropin, it derives an anabolic effect by increasing your LAPHT (Hypothalamic-Pituitary-Testicular-Axis) capacity which results in an increase in your testosterone production.

Insulin also increases the binding capacity of anabolic steroids to androgen receptors, which strongly suggests the possibility of a synergistic effect of insulin when combined with steroids. Most bodybuilders confirm that insulin has a certain anabolic synergy when combined with growth hormone.

The relationship between insulin, IGF and HGH is very synergistic and all actions interdependent on each other. Use all three together, plus anabolic steroids and a fat burner will give you the strongest and most powerful muscle you can get.

Of course, when something sounds too good to be true, there is always a BUT !!!!

Unfortunately, the bad news is that insulin can easily stimulate the storage of fat mass.

As a rule of thumb, most bodybuilders take insulin with a fat burner or thyroid hormones like t3-Cytomel, as well as anabolic steroids and sometimes even HGH and IGF, for the reasons explained above. All of this adds to the decrease in the likelihood that fat will be stored, and dramatically increases the amount of muscle that will be gained.

Individual insulin requirements are generally between 0,3 and 1,0 IU / kg / day. Make sure your insulin dose is limited to between 15 and 45 IU. But that will greatly depend on your daily carbohydrate intake. During a diet or during a cutting period, the dosage should be reduced further. Most bodybuilders use up to three insulin injections every day.

• The first dose occurs just after waking up,
• The second dose occurs somewhere near noon.
• The third and final consumption is done right after you have completed your workout for the day.

Actrapid HM Penfill Novo Nordisk Insulin Rapid

Normally, insulin is made by the pancreas and then released into the blood. It acts in a few seconds, and its production, which is called secretion, varies at all times according to the needs of the body. What is called rapid or regular insulin like Actrapid HM Penfill, is a laboratory-made insulin, which is the same as insulin made naturally by the human body.

However, if we know how to perfectly manufacture this insulin in the laboratory, we do not know (yet) how to pour it into the blood by varying its level at all times as needed. This is the big problem with its route of administration, knowing how it will be able to reach the bloodstream.

Since it is destroyed when it passes into the stomach, insulin cannot be taken as a tablet or in an oral ampoule. The only way that is used is the famous insulin injection, which is done by an injection under the skin (subcutaneous). But once the insulin is under the skin, it still has to travel to the blood vessels and that takes time. This is why so-called rapid insulin ultimately acts quite slowly. Its action begins about 15 to 30 minutes after the bite and lasts about 6 hours.

Humalog Lilly Novo Nordisk Insulin Rapid

Since rapid insulin acts too slowly for the rapid influx of carbohydrates from the meal, attempts have been made to develop faster insulins.

The researchers managed to slightly change the structure of insulin and resulted in a modified insulin that acts faster, stronger and for less time: these are the “fast insulin analogues” like HUMALOG insulin.

After subcutaneous administration, Humalog acts quickly and has a shorter duration of action (2 to 5 hours) than rapid insulin. This rapidity of action makes it possible to administer an injection of Humalog (or in the case of continuous subcutaneous administration, a bolus of Humalog) very shortly before or after a meal. The course of the action of any insulin over time can vary significantly from one subject to another or at different times in the same subject. The onset of action, which is faster compared to rapid human insulin, is maintained regardless of the injection site. As with all insulin preparations, the duration of action of Humalog depends on the dose, injection site, blood supply, temperature and physical activity.

Insulatard Penfill Novo Nordisk slow insulin

Regular insulin has a duration of action of about 6 hours. In order to achieve effects over 12 to 24 hours, researchers have developed insulins with a longer duration of action. They had the idea of ​​adding crystals of a product called Protamine to insulin: once injected subcutaneously, the insulin is released slowly and therefore acts longer. Thus was born insulin NPH as Insulatard.

It is an insulin identical to human insulin, obtained by biotechnology. Its duration of action is long: its effect appears approximately 1 hour 30 minutes after the injection and wears off after 24 hours. Insulatard is often taken in combination with fast-acting insulins.

This insulin should only be injected subcutaneously, trying to vary the injection sites to avoid the appearance of lipodystrophies (nodules and thickening of the skin).

Before injection, shake the suspension slowly in order to homogenize it.

For better comfort, the insulin can be taken out of the refrigerator one hour before the injection or warmed in the hands for a few minutes, then injected at room temperature.

In the event of sports activity, it is preferable to inject insulin away from the muscles worked during your training to avoid too rapid absorption.

Mixtard 30 HM Penfill Nordisk Mix slow and fast insulin

To avoid multiple insulin injections, the researchers came up with the idea of ​​mixing slow insulin (NPH) and rapid insulin (Actrapid).

This insulin mix is ​​called Mixtard (Novo Nordisk)

Mixtard is a mixture of fast-acting and long-acting insulin. This means that it starts to lower your blood sugar about half an hour after administration and the effect lasts for about 24 hours.

Insulin administration

Subcutaneously

Insulin is usually administered subcutaneously to the abdominal wall. The injections can also be carried out in the thigh, in the gluteal region or in the deltoid region.

A subcutaneous injection into the abdominal wall ensures faster absorption than at other injection sites.

Injection into a skin fold reduces the risk of accidental intramuscular injection.

After the injection, the needle should remain under the skin for at least 6 seconds to ensure that the full dose is injected.

The injection area is determined by the type of insulin to be injected. ...

Special storage precautions for insulin

Store between + 2 ° C and + 8 ° C (in the refrigerator), away from the freezing compartment.

Do not freeze.

Keep the container in the outer packaging to protect from light.

In use: do not put in the refrigerator.

Do not store above + 30 °.

Store away from excessive heat and light

Shelf life of insulin

Store unused insulin cartridges in the refrigerator until you need them. You can use them until the expiry date stated on the label. Avoid freezing.

You can keep the started insulin at room temperature, but you will need to throw it away after 28 days.